Lunasin's Mechanism as an Antioxidant and Hypocholesterolemic Agent

Santi Widiasari; Sabrina Hayati; May Valzon; Wahyu Ramadhan

doi:10.55606/ijhs.v5i1.5637

Authors

Santi Widiasari Universitas Abdurrab,
Sabrina Hayati Universitas Abdurrab
May Valzon Universitas Abdurrab
Wahyu Ramadhan Universitas Abdurrab

DOI:

https://doi.org/10.55606/ijhs.v5i1.5637

Keywords:

antioxidant, hypercholesterolemic agent, lunasin, soybean

Abstract

Several ways that can help lower cholesterol levels in the blood include using drugs (pharmacotherapy) or by modifying lifestyle and consuming certain foods. One of them is lunasin. Lunasin is a peptide found in soybean plants and is a promising drug candidate because it has broad health effects such as antioxidant, anti-inflammatory, anti-cancer, and lowering blood cholesterol through various mechanisms. This paper aims to examine the role and mechanism of action of lunasin as an antioxidant and its ability to lower blood cholesterol levels due to the unique peptide structure of lunasin as well as the bioavailability of lunasin starting from degradation, absorption, translocation and distribution of lunasin to target organs or target tissues after oral administration . This paper also discusses soybean plants as the main source of lunasin and the optimal content of lunasin in soybeans.

Downloads

Download data is not yet available.

References

1. Vaibhao Kisanrao Lule, Sheenam Garg, Sarang Dilip Pophaly, Hitesh, and Sudhir Kumar Tomar. “Potential Health Benefits of Lunasin: A Multifaceted Soy-Derived Bioactive Peptide” Journal of Food Science. 2015; 80(3): 485-494.

2. Gillian Jones and Ajay Srivastava.Understanding Lunasin's biology and potential as a cancer therapeutic by using Drosophila genetics. Experimental Biology and Medicine. 2014; 239: 519–528.

3. J. Liu, S.-H. Jia, M. Kirberger, N. Chen. Lunasin as a promising health-beneficial peptide. European Rev iew for Med ical and Pharmacol ogical Sci ences. 2014; 18: 2070-2075.

4. Miguel Guijarro-Díez, María Concepción García, Antonio Luis Crego, María Luisa Marina . Off-line two dimensional isoelectrofocusing-liquidchromatography/mass spectrometry (time of flight) for the determination of the bioactive peptide lunasin. Journal of Chromatography A,. 2014; 1371: 117–124.

5. Jeong HJ, Jeong JB, Kim DS, De Lumen BO. Inhibition of core histone acetylation by the cancer preventive peptide lunasin. J Agric Food Chem 2007;5: 632-637.

6. Jeong HJ, Jeong JB, Kim DS, Park JH, Lee JB, Kweon DH. The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Lett 2007; 255: 42-48.

7. Vermont P. Dia, Sofia Torres, Ben O. De Lumen, John W. Erdman Jr, Elvira Gonzales De Meija. Presence of Lunasin in Plasma of Men after Soy Protein Consumption. J. Agric. Food Chem. 2009; 57: 1260–1266.

8. Dia VP, Frankland-Searby S, Del HFL, Garcia G, De Mejia EG. Structural properties of soybean lunasin and development of a method to quantify lunasin in plasma using an optimized immunoassay protocol. Food Chem 2013; 138: 334-341.

9. Blanca Herna´ndez-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen. Lunasin, a novel seed peptide for cancer prevention. Peptides. 2009;30: 426–430.

10. Sirtori CR, Even R, Lovati MR. Soybean protein diet and plasma cholesterol: from therapy to molecular mechanisms. Ann NY Acad Sci. 1993; 676:188–201.

11. Sagara M, Kanda T, NJelekera M, Teramoto T, Armitage L, Birt N, Birt C, Yamori Y. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland. J Am Coll Nutr. 2004; 23:85–91.

12. Wang Y, Jones PJ, Ausman LM, Lichtenstein AH. Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects. Atherosclerosis. 2004; 173: 269–75.

13. Fang Zhong, Jianmin Liu, Jianguo Ma, Charles F. Shoemaker. Preparation of hypocholesterol peptides from soy protein and their hypocholesterolemic effect in mice. Food Research International. 2007;40: 661–667.

14. Hernandez-Ledesma B, Hsieh CC, De Lumen BO. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. Biochem Biophys Res Commun. 2009; 390: 803-808.

15. Huang, W.-Y., Majumder, K., Wu, J. Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interaction with

phytochemicals. Food Chem. 2010; 123: 635–641.

16. Dávalos, A., Gómez-Cordovés, C., Bartolomé, B.. Extending applicability of the oxygen radical absorbance capacity (ORAC Fluorescein) assay. J. Agric. Food Chem. 2004; 52: 48–54.

17. Li, Y.-W., Li, B. Characterization of structure–antioxidant activity relationship of peptides in free radical systems using QSAR models: key sequence positions and their amino acid properties. J. Theor. Biol. 2013; 318: 29–43.

18. Hernández-Ledesma, B., Dávalos, A., Bartolomé, B., Amigo, L. Preparation of antioxidant enzymatic hydrolyzates from -lactalbumin and -lactoglobulin. Identification of active peptides by HPLC-MS/MS. J. Agric. Food Chem. 2005; 53:588–593.

19. María José García-Nebot, Isidra Recio, Blanca Hernández-Ledesma. Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells. Food and Chemical Toxicology. 2014; 65: 155–161.

20. Hyung Jin Jeong, Jin Boo Jeong, Dae Seop Kim. The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Letters. 2007;255: 42–48.

21. Hernandez-Ledesma B, Hsieh CC, De Lumen BO. Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation. Mol Nutr Food Res. 2011; 55: 989–98.

22. Harvian Satya Dharma. The Role of Endogenous and Exogenous Antioxidants in Health. CDK-198 .2012; 39(10):793-794.